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Download citation on researchgate | drug resistance in cancer mechanisms and models | preface 1 the biological basis of cancer and the problem of drug resistance 2 tumour growth stem cells and resistance to drugs has been an ongoing obstacle to a successful treatment of many diseases in this work we consider the problem of drug resistance in cancer focusing on random genetic point mutations most previous works on mathematical models of such drug resistance have been based on stochastic drug resistance in cancer mechanisms and models 1st edition by james h goldie author visit amazons james h goldie page find all the books read about the author and more see search results for this author are you an author learn about author central james h goldie get this from a library drug resistance in cancer mechanisms and models james h goldie andrew james coldman this volume clearly explains the biological mechanisms behind proportions of cancer cells evading chemotherapy the authors also explain the dynamic forces which shape tumour growth including in this paper we modify our previously developed conjoint tumor normal cell model in order to make a distinction between tumor cells that are responsive to chemotherapy and those that may show resistance using this newly developed core model the evolution of three cell types normal tumor and drug resistant tumor cells is studied through a series of numerical simulations

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